Selected article for: "cell culture and virus infection"
Author: Li, Yunlong; Miao, Zhijiang; Li, Pengfei; Zhang, Ruyi; Kainov, Denis E.; Ma, Zhongren; de Man, Robert A.; Peppelenbosch, Maikel P.; Pan, Qiuwei
Title: Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1
  • Cord-id: 0e2skthv
  • Document date: 2021_5_14
    • ID: 0e2skthv
    Snippet: We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance. Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of iverme
    Document: We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance. Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermectin. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-05096-w.

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