Author: Choreno-Parra, Jose Alberto; Jimenez-Alvarez, Luis Armando; Lagunas, Alfredo Cruz; Rodriguez-Reyna, Tatiana Sofia; Ramirez-Martinez, Gustavo; Sandoval-Vega, Montserrat; Hernandez-Garcia, Diana Lizeth; Choreno-Parra, Eduardo M.; Balderas-Martinez, Yalbi I.; Martinez-Sanchez, Mariana Esther; Marquez-Garcia, Eduardo; Sciutto, Edda; Moreno-Rodriguez, Jose; Barreto-Rodriguez, Jose Omar; Vazquez-Rojas, Hazel; Centeno-Saenz, Gustavo Ivan; Alvarado-Pena, Nestor; Salinas-Lara, Citlaltepetl; Sanchez-Garibay, Carlos; Hernandez-Molina, Gabriela; Mendoza-Milla, Criselda; Dominguez, Andrea; Granados, Julio; Mena-Hernandez, Lula; Perez-Buenfil, Luis Angel; Dominguez-Cheritt, Guillermo; Cabello-Gutierrez, Carlos; Luna-Rivero, Cesar; Salas-Hernandez, Jorge; Santilla-Doherty, Patricio; Regalado, Justino; Hernandez-Martinez, Angelica; Orozco, Lorena; Garcia-Latorre, Ethel A.; Hernandez-Cardenas, Carmen M.; Khader, Shabaana A.; Zlotnik, Albert; Zuniga, Joaquin
Title: Clinical and immunological factors that distinguish COVID-19 from pandemic influenza A(H1N1) Cord-id: 0b33wufm Document date: 2020_8_14
ID: 0b33wufm
Snippet: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is a global health threat with the potential to cause severe disease manifestations in the lungs. Although clinical descriptions of COVID-19 are currently available, the factors distinguishing SARS-CoV-2 from other respiratory viruses are unknown. Here, we compared the clinical, histopathological, and immunological characteristics of patients with COVID-19 and pandemic in
Document: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is a global health threat with the potential to cause severe disease manifestations in the lungs. Although clinical descriptions of COVID-19 are currently available, the factors distinguishing SARS-CoV-2 from other respiratory viruses are unknown. Here, we compared the clinical, histopathological, and immunological characteristics of patients with COVID-19 and pandemic influenza A(H1N1). We observed a higher frequency of respiratory symptoms, increased tissue injury markers, a histological pattern of alveolar pneumonia, and higher levels of IL-1RA, TNF-, CCL3, G-CSF, APRIL, sTNF-R1, sTNF-R2, sCD30, and sCD163 in influenza patients. Conversely, dry cough, gastrointestinal symptoms, interstitial lung pathology, increased Th1 (IL-12, IFN-{gamma}) and Th2 (IL-4, IL-5, IL-10, IL-13) cytokine levels, along with IL-1{beta}, IL-6, CCL11, VEGF, TWEAK, TSLP, MMP-1, and MMP-3, were observed in COVID-19 cases. We demonstrated the diagnostic potential of some clinical and immune factors to differentiate COVID-19 from pandemic influenza A(H1N1). Our data suggest that SARS-CoV-2 induces a dysbalanced polyfunctional inflammatory response that is different from the immune response against influenza. These findings might be relevant for the upcoming 2020-2021 influenza season, which is projected to be historically unique due to its convergence with COVID-19.
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