Selected article for: "CTD subtype and layer CTD subtype"
Author: Jinfang Yu; Shuyuan Qiao; Runyu Guo; Xinquan Wang
Title: Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins and insights into coronavirus evolution
  • Document date: 2020_2_24
    • ID: 25va2cvt_17
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.23.961912 doi: bioRxiv preprint binding their respective protein receptors 45 . In the CTD of HKU2, there is only one 245 short loop between the β5 and β6 strands of the core twisted β-sheet (Fig. 3a) . 246 Although as members in the α-genus, HKU2 and SADS-CoV CTD structures are 247 significantly different from those of other α-coron.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.23.961912 doi: bioRxiv preprint binding their respective protein receptors 45 . In the CTD of HKU2, there is only one 245 short loop between the β5 and β6 strands of the core twisted β-sheet (Fig. 3a) . 246 Although as members in the α-genus, HKU2 and SADS-CoV CTD structures are 247 significantly different from those of other α-coronaviruses HCoV-NL63, HCoV-229E, 248 PEDV, TGEV and PRCV that contain two layers of β-sheets (Fig. 3c) . And we named 249 these CTDs as two-layer CTD subtype. All available two-layer CTD structures can be 250 well aligned with Cα r.m.s.d. in the range of 1.0-3.4 Å, except for the CTDs of HKU2 251 and SADS-CoV. These two-layer CTDs contain two highly conserved disulfide bonds: 252 C 540 -C 586 and C 569 -C 596 (numbered in PEDV CTD) (Fig. 3c ). The C 569 -C 596 is conserved 253 among all coronaviruses, whereas the C 540 -C 586 is conserved in all α-coronaviruses 254 (except for HKU2 and SADS) and δ-coronavirus PdCoV (Fig. 3c) .

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