Selected article for: "effective immune response and immune response"
Author: Danilenko, E. D.; Belkina, A. O.; Sysoeva, G. M.
Title: Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy
  • Cord-id: 03sqz89c
  • Document date: 2019_12_4
    • ID: 03sqz89c
    Snippet: Abstract—The review summarizes literature data on the development of drugs based on natural and synthetic high-polymeric double-stranded RNA (dsRNA), their antiviral, immunoadjuvant, and antitumor properties. Special attention is paid to cell receptors responding to exogenous dsRNA, pathways of dsRNA-dependent antiviral reaction, ability of dsRNA to inhibit growth and induce apoptosis of malignant cells. It has been shown that enhancing the innate immune response with dsRNA can be an effective
    Document: Abstract—The review summarizes literature data on the development of drugs based on natural and synthetic high-polymeric double-stranded RNA (dsRNA), their antiviral, immunoadjuvant, and antitumor properties. Special attention is paid to cell receptors responding to exogenous dsRNA, pathways of dsRNA-dependent antiviral reaction, ability of dsRNA to inhibit growth and induce apoptosis of malignant cells. It has been shown that enhancing the innate immune response with dsRNA can be an effective component in improving methods for treating and preventing infectious and cancer diseases. The further use of dsRNA for the correction of pathological processes of different origin is discussed.

    Search related documents:
    Co phrase search for related documents
    • absence presence and acid inducible gene: 1
    • absence presence and action mechanism: 1, 2, 3, 4, 5, 6
    • absence presence and activate receptor: 1, 2
    • absence presence and activation binding: 1, 2, 3, 4, 5, 6
    • absence presence and activation induction: 1, 2
    • absence presence and activation pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • absence presence and activation promote: 1
    • absence presence and active component: 1
    • absence presence and active ingredient: 1
    • absence presence and acute phase: 1, 2, 3, 4, 5, 6, 7, 8
    • absence presence and acute respiratory infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • absence presence and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
    • absence presence and adenocarcinoma cell: 1
    • absence presence and low toxicity: 1, 2
    • absence presence and lymph node: 1, 2, 3, 4, 5
    • acid delivery and action mechanism: 1
    • acid delivery and activate effect: 1
    • acid delivery and low immunogenicity: 1, 2
    • acid delivery and low toxicity: 1, 2