Selected article for: "copy number and expression level"
Author: A. Sina Booeshaghi; Lior Pachter
Title: Decrease in ACE2 mRNA expression in aged mouse lung
  • Document date: 2020_4_5
    • ID: 0pocrjvk_4
    Snippet: To examine mRNA abundance of ACE2 in young and old mice lungs, we began by uniformly processing 9,10 all RNA-seq from GSE12487 6 (see Methods), followed by computation of common coordinates for the 3-month and 24-month old mice single-cell RNA-seq using scVI 11 (Figure 1a , Methods). Consistent with previous findings 12 , we find that ACE2 is not prevalent in the lung, with the exception of Goblet/Club and ciliated cells (Supp. Fig. 1 ). In cells.....
    Document: To examine mRNA abundance of ACE2 in young and old mice lungs, we began by uniformly processing 9,10 all RNA-seq from GSE12487 6 (see Methods), followed by computation of common coordinates for the 3-month and 24-month old mice single-cell RNA-seq using scVI 11 (Figure 1a , Methods). Consistent with previous findings 12 , we find that ACE2 is not prevalent in the lung, with the exception of Goblet/Club and ciliated cells (Supp. Fig. 1 ). In cells where ACE2 mRNA molecules are identified, the average copy number is 1.19. We, therefore, measured the expression level of ACE2 by the proportion of cells with at least one copy (Methods).

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