Selected article for: "age decrease and expression decrease"
Author: A. Sina Booeshaghi; Lior Pachter
Title: Decrease in ACE2 mRNA expression in aged mouse lung
  • Document date: 2020_4_5
    • ID: 0pocrjvk_6
    Snippet: The decrease in ACE2 mRNA expression with age in lungs is likely due to two underlying phenomena: a reduction of ACE2 mRNA in ciliated cells, and a shift in ciliated cell abundance with age (Figure 1c, Supp. Fig 4) . The latter result is statistically significant and corroborated in an analysis of FACS sorted cells 6 . SARS-CoV-2 uses the serine protease TMPRSS2 for Spike protein priming, so we repeated our analyses for TMPRSS2 . We found no sig.....
    Document: The decrease in ACE2 mRNA expression with age in lungs is likely due to two underlying phenomena: a reduction of ACE2 mRNA in ciliated cells, and a shift in ciliated cell abundance with age (Figure 1c, Supp. Fig 4) . The latter result is statistically significant and corroborated in an analysis of FACS sorted cells 6 . SARS-CoV-2 uses the serine protease TMPRSS2 for Spike protein priming, so we repeated our analyses for TMPRSS2 . We found no significant changes in mRNA expression between 3-month and 24-month old mice (Supp. Figs. 5-7 ).

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