Author: Siying Ye; Chris Cowled; Cheng-Hon Yap; John Stambas
Title: Deep sequencing of primary human lung epithelial cells challenged with H5N1 influenza virus reveals a proviral role for CEACAM1 Document date: 2018_5_17
ID: 6arj2i3m_26
Snippet: In summary, molecules on the cell surface such as CEACAM1 are particularly attractive 368 candidates for therapeutic development, as drugs do not need to cross the cell membrane in order to be 369 effective. Targeting of host-encoded genes in combination with current antivirals and vaccines may be 370 a way of reducing morbidity and mortality associated with influenza virus infection. Our study clearly 371 demonstrates that increased CEACAM1 expr.....
Document: In summary, molecules on the cell surface such as CEACAM1 are particularly attractive 368 candidates for therapeutic development, as drugs do not need to cross the cell membrane in order to be 369 effective. Targeting of host-encoded genes in combination with current antivirals and vaccines may be 370 a way of reducing morbidity and mortality associated with influenza virus infection. Our study clearly 371 demonstrates that increased CEACAM1 expression is observed in primary human ATII cells infected 372 with highly pathogenic H5N1 influenza virus. Importantly, knockdown of CEACAM1 expression 373 All rights reserved. No reuse allowed without permission.
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