Nuclear Receptors, Ligands and the Mammalian B Cell

Jones, Bart G.; Penkert, Rhiannon R.; Surman, Sherri L.; Sealy, Robert E.; Hurwitz, Julia L.

Questions concerning the influences of nuclear receptors and their ligands on mammalian B cells are vast in number. Here, we briefly review the effects of nuclear receptor ligands, including estrogen and vitamins, on immunoglobulin production and protection from infectious diseases. We describe nuclear receptor interactions with the B cell genome and the potential mechanisms of gene regulation. Attention to the nuclear receptor/ligand regulation of B cell function may help optimize B cell responses, improve pathogen clearance, and prevent damaging responses toward inert- and self-antigens.