Selected article for: "diagnosis time and negative test"
Author: Aditi Shastri; Justin Wheat; Sachee Agrawal; Nirjhar Chaterjee; Kith Pradhan; Mendel Goldfinger; Noah Kornblum; Ulrich Steidl; Amit Verma; Jayanthi Shastri
Title: Delayed clearance of SARS-CoV2 in male compared to female patients: High ACE2 expression in testes suggests possible existence of gender-specific viral reservoirs
  • Document date: 2020_4_17
    • ID: mm0k41mn_7
    Snippet: The clinical protocol was IRB approved by the Kasturba Hospital for Infectious Diseases Institutional Review Board on April 7, 2020. The first positive case for SARS-CoV 2 was detected in Mumbai on March 11th 2020 . Patients with suspected symptoms were admitted to the isolation ward at the Kasturba Hospital & monitored. Nasopharyngeal/ orophryngeal swabs collected at the time of diagnosis were analyzed by RT-PCR for positivity/negativity per the.....
    Document: The clinical protocol was IRB approved by the Kasturba Hospital for Infectious Diseases Institutional Review Board on April 7, 2020. The first positive case for SARS-CoV 2 was detected in Mumbai on March 11th 2020 . Patients with suspected symptoms were admitted to the isolation ward at the Kasturba Hospital & monitored. Nasopharyngeal/ orophryngeal swabs collected at the time of diagnosis were analyzed by RT-PCR for positivity/negativity per the Berlin protocol. 8 Subsequent swabs were collected at approximately 48 hours intervals until the swab test was documented to be negative. Persons residing in the same household as the index case as well as contacts were also tested. A log rank test was used to compare the difference in viral clearance between males and females and is represented in Figure 1 .B using Kaplan-Meier curves. Mean & median times towards viral clearance were also calculated for each gender. Statistical calculations and analysis were performed in the R version 3.6.1 environment.

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