Author: Daniel L. Hurdiss; Ieva Drulyte; Yifei Lang; Tatiana M. Shamorkina; Matti F. Pronker; Frank J.M. van Kuppeveld; Joost Snijder; Raoul J. de Groot
Title: Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans Document date: 2020_3_25
ID: 5lld270m_1
Snippet: : Structure determination of HKU1 HE by single-particle analysis. A) Representative motion-corrected electron micrograph of HKU1 HE embedded in vitreous ice. B) Representative reference-free 2D class averages. C) Orthogonal views of the HKU1 HE EM density (coloured by subunit). D) Cartoon representation of the atomic model of the dimeric HKU1 HE complex. E) EM density (blue mesh) zoned 2 Å around an α-helix comprising residues 112-132. F) EM de.....
Document: : Structure determination of HKU1 HE by single-particle analysis. A) Representative motion-corrected electron micrograph of HKU1 HE embedded in vitreous ice. B) Representative reference-free 2D class averages. C) Orthogonal views of the HKU1 HE EM density (coloured by subunit). D) Cartoon representation of the atomic model of the dimeric HKU1 HE complex. E) EM density (blue mesh) zoned 2 Å around an α-helix comprising residues 112-132. F) EM density (blue mesh) zoned 2 Å around a β-sheet comprising residues 181-188, 219-224 and 243-248.
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