Selected article for: "binding site and sialic acid"
Author: Daniel L. Hurdiss; Ieva Drulyte; Yifei Lang; Tatiana M. Shamorkina; Matti F. Pronker; Frank J.M. van Kuppeveld; Joost Snijder; Raoul J. de Groot
Title: Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans
  • Document date: 2020_3_25
    • ID: 5lld270m_3
    Snippet: The overall fold of HKU1 HE is like those of related embecoviruses, murine coronavirus (MHV) Figure 2 : Comparison of HKU1 HE to related embecoviruses. A) Linear representation of HE domain organisation. The membrane proximal domain (MPD), esterase domain (E) and receptor domain (R) are coloured red, green and blue, respectively. Grey segments indicate the signal- peptide (SP) and transmembrane (TM) domain. The bracket indicates the part of the .....
    Document: The overall fold of HKU1 HE is like those of related embecoviruses, murine coronavirus (MHV) Figure 2 : Comparison of HKU1 HE to related embecoviruses. A) Linear representation of HE domain organisation. The membrane proximal domain (MPD), esterase domain (E) and receptor domain (R) are coloured red, green and blue, respectively. Grey segments indicate the signal- peptide (SP) and transmembrane (TM) domain. The bracket indicates the part of the protein for which the structure of HKU1 HE was solved. B) Ribbon representation of the dimeric HKU1 HE (residues 15-346), C) MHV-NJ HE (PDB ID: 5JIL, residues 20-388) and BCoV-Mebus HE (PDB ID: 3CL5, residues 19-376) structures. One monomer is coloured grey, the other by domain organisation shown in (A). Bound 4-O-acetylated (MHV) or 9-Oacetylated (BCoV) sialic acid is coloured orange. Sodium (MHV) and potassium (BCoV) ions are coloured purple and zinc is grey. E) Expanded view of the region corresponding to the LD carbohydrate-binding site (CBS) in HKU1 HE, (F) MHV, and (G) BCoV.

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