Author: Liu, Zhi-Ping; Wu, Ling-Yun; Wang, Yong; Zhang, Xiang-Sun; Chen, Luonan
Title: Bridging protein local structures and protein functions Cord-id: 0oq2n0af Document date: 2008_4_18
ID: 0oq2n0af
Snippet: One of the major goals of molecular and evolutionary biology is to understand the functions of proteins by extracting functional information from protein sequences, structures and interactions. In this review, we summarize the repertoire of methods currently being applied and report recent progress in the field of in silico annotation of protein function based on the accumulation of vast amounts of sequence and structure data. In particular, we emphasize the newly developed structure-based metho
Document: One of the major goals of molecular and evolutionary biology is to understand the functions of proteins by extracting functional information from protein sequences, structures and interactions. In this review, we summarize the repertoire of methods currently being applied and report recent progress in the field of in silico annotation of protein function based on the accumulation of vast amounts of sequence and structure data. In particular, we emphasize the newly developed structure-based methods, which are able to identify locally structural motifs and reveal their relationship with protein functions. These methods include computational tools to identify the structural motifs and reveal the strong relationship between these pre-computed local structures and protein functions. We also discuss remaining problems and possible directions for this exciting and challenging area.
Search related documents:
Co phrase search for related documents- accessible surface and active area: 1
- accessible surface and active site: 1, 2
- accessible surface and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- accessible surface area and active area: 1
- accessible surface area and active site: 1
- accessible surface area and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9
- accuracy improve and active area: 1, 2
- accuracy improve and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- accuracy value and acid nucleotide: 1
- accuracy value and active area: 1
- accuracy value and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- accurate rapid and active site: 1
- accurate rapid and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- accurate rapid method and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7
- acid nucleotide and active site: 1, 2, 3, 4
- acid nucleotide and active site residue: 1
- acid nucleotide and active site template: 1
- acid nucleotide and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- active area and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
Co phrase search for related documents, hyperlinks ordered by date