Selected article for: "bind protein and protein protein"
Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses
  • Document date: 2020_3_14
    • ID: n7ylgqfu_78
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint mean disorder analysis (see Figures 21A, 21B, and 21C) , Nsp3 proteins are predicted to have the following IDPRs, SARS-CoV-2 (1-5, [1221] [1222] [1223] [1224] [1225] [1226] [1227] [1228] [1229] [1230] [1231] [1232] [1233] [1234] [1235] [1236] [1237] [1238] , Human SARS (102-189, 355-384, 1195-1223) and Bat .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint mean disorder analysis (see Figures 21A, 21B, and 21C) , Nsp3 proteins are predicted to have the following IDPRs, SARS-CoV-2 (1-5, [1221] [1222] [1223] [1224] [1225] [1226] [1227] [1228] [1229] [1230] [1231] [1232] [1233] [1234] [1235] [1236] [1237] [1238] , Human SARS (102-189, 355-384, 1195-1223) and Bat CoV (107-182, 352-376, 1191-1217) . The First 112 residues in Nsp3 represent a ubiquitin-like globular fold while 113-183 residues form the flexible acidic domain rich in glutamic acid. It is thought to bind and ubiquitinate viral E protein using the N-terminal acidic domain [132, 133] . This unstructured segment has many MoRFs predicted by ANCHOR and MoRFPred servers which may facilitate the protein-protein interaction ( Table 2) . Interestingly, Nsp3 of all three viruses was found with highest number of RNAbinding residues (Supplementary Tables 9, 10, and 11) .

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