Selected article for: "mutant virion and wild type"
Author: Sebastian J. Schreiber; Ruian Ke; Claude Loverdo; Miran Park; Priyanna Ahsan; James O. Lloyd-Smith
Title: Cross-scale dynamics and the evolutionary emergence of infectious diseases
  • Document date: 2016_7_29
    • ID: hain3be0_24
    Snippet: Whether a selective advantage at either scale results in the mutant reproductive number R m exceeding one depends on the duration of the infection. For short-term infections, most transmissions occur towards the end of the infectious period T , when the infectious load is the highest. By the end of the infectious period, the mutant viral density has increased approximately by a factor of e sT more than the wild-type, and transmission for each mut.....
    Document: Whether a selective advantage at either scale results in the mutant reproductive number R m exceeding one depends on the duration of the infection. For short-term infections, most transmissions occur towards the end of the infectious period T , when the infectious load is the highest. By the end of the infectious period, the mutant viral density has increased approximately by a factor of e sT more than the wild-type, and transmission for each mutant virion is exp(Ï„ ) more likely than for a wild-type virion. Refining this intuition, we derive the approximation (Appendix)

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