Author: Sebastian J. Schreiber; Ruian Ke; Claude Loverdo; Miran Park; Priyanna Ahsan; James O. Lloyd-Smith
Title: Cross-scale dynamics and the evolutionary emergence of infectious diseases Document date: 2016_7_29
ID: hain3be0_26
Snippet: This approximation implies that a between-host selective advantage is required for a long-term infection to be capable of evolutionary emergence (confirmed by exact calculations in Fig 2C) . When viral dynamics are dominated by the saturated phase at fixed K, a within-host selective advantage has little impact on the average viral load during the infectious period of an individual solely infected with the mutant strain and, consequently, provides.....
Document: This approximation implies that a between-host selective advantage is required for a long-term infection to be capable of evolutionary emergence (confirmed by exact calculations in Fig 2C) . When viral dynamics are dominated by the saturated phase at fixed K, a within-host selective advantage has little impact on the average viral load during the infectious period of an individual solely infected with the mutant strain and, consequently, provides a minimal increase in the mutant reproductive number.
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