Author: Flora Mariajoseph-Antony, Lezy; Kannan, Arun; Panneerselvam, Antojenifer; Loganathan, Chithra; Anbarasu, Kumarasamy; Prahalathan, Chidambaram
Title: Could Aquaporin Modulators Be Employed As Prospective Drugs For COVID- 19 Related Pulmonary Comorbidity? Cord-id: 0kjxk1sl Document date: 2020_8_17
ID: 0kjxk1sl
Snippet: Covid-19 initially an epidemic caused by SARS-CoV-2 has turned out to be a life- threatening global pandemic with increased morbidity and mortality. The presence of cytokine storm has been linked with the pathogenesis of severe lung injury as evinced in Covid-19. Aquaporins (AQPs) are molecular water channels, facilitating water transport across the cell membrane in response to osmotic gradients. Impairment in alveolar fluid clearance due to altered functional expression of respiratory AQPs high
Document: Covid-19 initially an epidemic caused by SARS-CoV-2 has turned out to be a life- threatening global pandemic with increased morbidity and mortality. The presence of cytokine storm has been linked with the pathogenesis of severe lung injury as evinced in Covid-19. Aquaporins (AQPs) are molecular water channels, facilitating water transport across the cell membrane in response to osmotic gradients. Impairment in alveolar fluid clearance due to altered functional expression of respiratory AQPs highlight their pathophysiological significance in pulmonary edema associated respiratory illness. Therefore, we hypothesize that targeted modulation of AQPs in lungs in the intervening period of time, could diminish the dreadful effects of inflammation- induced comorbidity in Covid-19.
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