Author: Yuanmei Zhu; Danwei Yu; Hongxia Yan; Huihui Chong; Yuxian He
Title: Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity Document date: 2020_3_28
ID: cogk5kig_14
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.26.009233 doi: bioRxiv preprint C-terminal sequences contributed critically to the binding of the inhibitors (Table 1) analyzing the secondary structure and thermostability with CD spectroscopy, we found that 206 the HR1 peptide derived from the S2 fusion protein of SARS-CoV-2 displays much higher 207 α-helicity and thermostability than .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.26.009233 doi: bioRxiv preprint C-terminal sequences contributed critically to the binding of the inhibitors (Table 1) analyzing the secondary structure and thermostability with CD spectroscopy, we found that 206 the HR1 peptide derived from the S2 fusion protein of SARS-CoV-2 displays much higher 207 α-helicity and thermostability than the HR1 peptide from the S2 fusion protein of SARS-CoV. 208 Consistently, both the α-helical contents and melting temperature of the SARS-CoV-2 HR1 209 author/funder. All rights reserved. No reuse allowed without permission.
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