Selected article for: "Sirna module and target site"
Author: Asiedu Ebenezer
Title: Designing Effective small interfering RNA for Post-Transcriptional Silencing of Human GREM1: A Comprehensive Bioinformatics Approach
  • Document date: 2020_1_24
    • ID: j99qg2a0_17
    Snippet: The accessibility of the siRNA target sites was analyzed using the Sfold server (http://sfold.wadsworth.org/cgi-bin/index.pl). The Sirna module was particularly used for this activity. The Sirna module is for rational design of siRNA considering proposed rules for siRNA design, duplex thermodynamics and target site accessibility [28] . Given a target mRNA as input, the algorithm evaluates accessibility of the target site using parameters such as .....
    Document: The accessibility of the siRNA target sites was analyzed using the Sfold server (http://sfold.wadsworth.org/cgi-bin/index.pl). The Sirna module was particularly used for this activity. The Sirna module is for rational design of siRNA considering proposed rules for siRNA design, duplex thermodynamics and target site accessibility [28] . Given a target mRNA as input, the algorithm evaluates accessibility of the target site using parameters such as probability profiles and loop specific profiles. Internal stability profiles of siRNA for particular target positions were also analyzed.

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