Author: Irving, Melita B; Pan, Oscar; Scott, Jamie K
Title: Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics Cord-id: 1xt46g8j Document date: 2001_6_1
ID: 1xt46g8j
Snippet: Random peptide libraries and antigen-fragment libraries (also known as gene-fragment libraries) have been used to identify epitopes on protein antigens. These technologies promise to make significant contributions to diagnostic and vaccine development. Researchers in a number of labs have shown that phage selected from libraries with protective antibodies, raised against whole antigen, can be used as immunogens to stimulate antibody responses that bind native antigen and provide protection in vi
Document: Random peptide libraries and antigen-fragment libraries (also known as gene-fragment libraries) have been used to identify epitopes on protein antigens. These technologies promise to make significant contributions to diagnostic and vaccine development. Researchers in a number of labs have shown that phage selected from libraries with protective antibodies, raised against whole antigen, can be used as immunogens to stimulate antibody responses that bind native antigen and provide protection in vivo. Others have used the sera of patients with idiopathic diseases to screen libraries, and by this approach have identified candidate antigens involved in immune disease. These may prove useful for diagnosis and, possibly, in determining disease etiology.
Search related documents:
Co phrase search for related documents- ab binding and ab response: 1
- ab binding and abs antibodies: 1, 2, 3
- ab binding and abs generate: 1
- ab binding and lysine residue: 1
- ab binding and mabs neutralize: 1
Co phrase search for related documents, hyperlinks ordered by date