Selected article for: "effective silencing and mrna target"

Author: Asiedu Ebenezer
Title: Designing Effective small interfering RNA for Post-Transcriptional Silencing of Human GREM1: A Comprehensive Bioinformatics Approach
  • Document date: 2020_1_24
  • ID: j99qg2a0_27
    Snippet: In this study, empirical guidelines for siRNA design and mRNA target accessibility have been comprehensively applied to select siRNA candidates that possess features for effective siRNA-mediated silencing of human gremlin-1. Gremlin-1 is a crucial signaling element for several biological pathways. During vertebrate limb development, gremlin-1 antagonizes bone morphogenetic proteins to maintain mechanisms for proper limb bud patterning [32] ......
    Document: In this study, empirical guidelines for siRNA design and mRNA target accessibility have been comprehensively applied to select siRNA candidates that possess features for effective siRNA-mediated silencing of human gremlin-1. Gremlin-1 is a crucial signaling element for several biological pathways. During vertebrate limb development, gremlin-1 antagonizes bone morphogenetic proteins to maintain mechanisms for proper limb bud patterning [32] .

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