Selected article for: "coronavirus infection and respiratory tract"
Author: Khan, Mujeeb; Adil, Syed F.; Alkhathlan, Hamad Z.; Tahir, Muhammad N.; Saif, Sadia; Khan, Merajuddin; Khan, Shams T.
Title: COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far
  • Cord-id: 0sxpecee
  • Document date: 2020_12_23
    • ID: 0sxpecee
    Snippet: Humans have witnessed three deadly pandemics so far in the twenty-first century which are associated with novel coronaviruses: SARS, Middle East respiratory syndrome (MERS), and COVID-19. All of these viruses, which are responsible for causing acute respiratory tract infections (ARTIs), are highly contagious in nature and/or have caused high mortalities. The recently emerged COVID-19 disease is a highly transmittable viral infection caused by another zoonotic novel coronavirus named severe acute
    Document: Humans have witnessed three deadly pandemics so far in the twenty-first century which are associated with novel coronaviruses: SARS, Middle East respiratory syndrome (MERS), and COVID-19. All of these viruses, which are responsible for causing acute respiratory tract infections (ARTIs), are highly contagious in nature and/or have caused high mortalities. The recently emerged COVID-19 disease is a highly transmittable viral infection caused by another zoonotic novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Similar to the other two coronaviruses such as SARS-CoV-1 and MERS-CoV, SARS-CoV-2 is also likely to have originated from bats, which have been serving as established reservoirs for various pathogenic coronaviruses. Although, it is still unknown how SARS-CoV-2 is transmitted from bats to humans, the rapid human-to-human transmission has been confirmed widely. The disease first appeared in Wuhan, China, in December 2019 and quickly spread across the globe, infected 48,539,872 people, and caused 1,232,791 deaths in 215 countries, and the infection is still spreading at the time of manuscript preparation. So far, there is no definite line of treatment which has been approved or vaccine which is available. However, different types of potential vaccines and therapeutics have been evaluated and/or are under clinical trials against COVID-19. In this review, we summarize different types of acute respiratory diseases and briefly discuss earlier outbreaks of coronaviruses and compare their occurrence and pathogenicity with the current COVID-19 pandemic. Various epidemiological aspects of COVID-19 such as mode of spread, death rate, doubling time, etc., have been discussed in detail. Apart from this, different technical issues related to the COVID-19 pandemic including use of masks and other socio-economic problems associated with the pandemic have also been summarized. Additionally, we have reviewed various aspects of patient management strategies including mechanism of action, available diagnostic tools, etc., and also discussed different strategies for the development of effective vaccines and therapeutic combinations to deal with this viral outbreak. Overall, by the inclusion of various references, this review covers, in detail, the most important aspects of the COVID-19 pandemic.

    Search related documents:
    Co phrase search for related documents
    • accurate diagnosis and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5
    • accurate diagnosis and acute pneumonia: 1, 2, 3, 4, 5
    • accurate diagnosis and acute respiratory illness: 1, 2, 3, 4, 5, 6
    • accurate diagnosis and acute respiratory infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • accurate diagnosis and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • accurate diagnosis and acute respiratory tract infection: 1, 2
    • accurate laboratory testing and acute respiratory infection: 1
    • accurate laboratory testing and acute respiratory syndrome: 1, 2, 3, 4, 5, 6
    • action possible mechanism and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • active case and acute ards respiratory distress syndrome: 1
    • active case and acute pneumonia: 1, 2, 3, 4, 5, 6, 7, 8
    • active case and acute respiratory illness: 1, 2, 3, 4
    • active case and acute respiratory illness outbreak: 1
    • active case and acute respiratory infection: 1, 2, 3, 4, 5
    • active case and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • active case and acute respiratory tract infection: 1, 2
    • actual origin and acute respiratory syndrome: 1, 2, 3