Author: Arkin, Lisa M.; Moon, John J.; Tran, Jennifer M.; Asgari, Samira; O’Farrelly, Cliona; Casanova, Jean-Laurent; Cowen, Edward W.; Mays, Jacqueline W.; Singh, Anne Marie; Drolet, Beth A.
Title: From your nose to your toes: A Review of SARS-CoV-2 Pandemic-associated Pernio Cord-id: 0giadhrs Document date: 2021_7_15
ID: 0giadhrs
Snippet: Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to SARS-CoV-2. Pernio in uninfected children is associated with monogenic disorders of excessive type 1 interferon (IFN-1) immunity, while severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of pandemic-associated pernio, suggesting an excessive innate immune
Document: Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to SARS-CoV-2. Pernio in uninfected children is associated with monogenic disorders of excessive type 1 interferon (IFN-1) immunity, while severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.
Search related documents:
Co phrase search for related documents- acid sensing and acute respiratory: 1, 2, 3, 4, 5
- acral site and acute infection: 1
- acute infection and adaptive immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- acute infection and local response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- acute infection and long history: 1, 2, 3, 4, 5, 6, 7, 8, 9
- acute infection and low amount: 1
- acute infection and lymphocytic infiltrate: 1
- acute respiratory and adaptive immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40
- acute respiratory and local response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42
- acute respiratory and long history: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27
- acute respiratory and low amount: 1, 2, 3, 4
- acute respiratory and lymphocytic infiltrate: 1, 2, 3, 4
- adaptive immune system and local response: 1, 2
- adaptive immune system and low amount: 1
Co phrase search for related documents, hyperlinks ordered by date