Author: Arkin, Lisa M.; Moon, John J.; Tran, Jennifer M.; Asgari, Samira; O’Farrelly, Cliona; Casanova, Jean-Laurent; Cowen, Edward W.; Mays, Jacqueline W.; Singh, Anne Marie; Drolet, Beth A.
Title: From your nose to your toes: A Review of SARS-CoV-2 Pandemic-associated Pernio Cord-id: 0giadhrs Document date: 2021_7_15
ID: 0giadhrs
Snippet: Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to SARS-CoV-2. Pernio in uninfected children is associated with monogenic disorders of excessive type 1 interferon (IFN-1) immunity, while severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of pandemic-associated pernio, suggesting an excessive innate immune
Document: Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to SARS-CoV-2. Pernio in uninfected children is associated with monogenic disorders of excessive type 1 interferon (IFN-1) immunity, while severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.
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