Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases

Ortega, Miguel Ángel; Guzmán Merino, Alberto; Fraile-Martínez, Oscar; Recio-Ruiz, Judith; Pekarek, Leonel; G. Guijarro, Luis; García-Honduvilla, Natalio; Álvarez-Mon, Melchor; Buján, Julia; García-Gallego, Sandra

Infectious diseases are one of the main global public health risks, predominantly caused by viruses, bacteria, fungi, and parasites. The control of infections is founded on three main pillars: prevention, treatment, and diagnosis. However, the appearance of microbial resistance has challenged traditional strategies and demands new approaches. Dendrimers are a type of polymeric nanoparticles whose nanometric size, multivalency, biocompatibility, and structural perfection offer boundless possibilities in multiple biomedical applications. This review provides the reader a general overview about the uses of dendrimers and dendritic materials in the treatment, prevention, and diagnosis of highly prevalent infectious diseases, and their advantages compared to traditional approaches. Examples of dendrimers as antimicrobial agents per se, as nanocarriers of antimicrobial drugs, as well as their uses in gene transfection, in vaccines or as contrast agents in imaging assays are presented. Despite the need to address some challenges in order to be used in the clinic, dendritic materials appear as an innovative tool with a brilliant future ahead in the clinical management of infectious diseases and many other health issues.