Author: Jinfang Yu; Shuyuan Qiao; Runyu Guo; Xinquan Wang
Title: Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins and insights into coronavirus evolution Document date: 2020_2_24
ID: 25va2cvt_35
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.23.961912 doi: bioRxiv preprint and this insertion responsible for receptor binding of ï¢-coronaviruses is replaced by a 393 short loop in HKU2 CTD. This result firstly indicates HKU2 CTD represent a primitive 394 structure in the one-layer CTD family, while the inserted domain in ï¢-coronaviruses 395 results from a recombinant event du.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.23.961912 doi: bioRxiv preprint and this insertion responsible for receptor binding of ï¢-coronaviruses is replaced by a 393 short loop in HKU2 CTD. This result firstly indicates HKU2 CTD represent a primitive 394 structure in the one-layer CTD family, while the inserted domain in ï¢-coronaviruses 395 results from a recombinant event during evolution (Supplementary Fig. 7c) . The second 396 indication is that HKU2 and SADS-CoV may not utilize the CTD to bind protein 397 receptors that have not been identified yet, and their different receptor usage may be 398 determined by the NTD that harbors almost 50% of residue difference between them.
Search related documents:
Co phrase search for related documents- different receptor usage and receptor usage: 1, 2, 3, 4, 5, 6, 7, 8, 9
- inserted domain and receptor binding: 1, 2, 3, 4, 5, 6, 7, 8, 9
- protein bind and receptor binding: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- protein bind and short loop: 1
- receptor binding and residue difference: 1
- receptor binding and short loop: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date