Author: Lehene, Maria; Fischer-Fodor, Eva; Scurtu, Florina; Hădade, Niculina D.; Gal, Emese; Mot, Augustin C.; Matei, Alina; Silaghi-Dumitrescu, Radu
Title: Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells Cord-id: 1f2j9o3t Document date: 2020_5_27
ID: 1f2j9o3t
Snippet: Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological
Document: Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.
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