Author: Levy, Jerrold H.; Iba, Toshiaki; Olson, Lyra B.; Corey, Kristen M.; Ghadimi, Kamrouz; Connors, Jean M.
Title: COVIDâ€19: Thrombosis, thromboinflammation, and anticoagulation considerations Cord-id: 0u3uka3w Document date: 2021_7_20
ID: 0u3uka3w
Snippet: Vascular endothelial injury is a hallmark of acute infection at both the microvascular and macrovascular levels. The hallmark of SARSâ€CoVâ€2 infection is the current COVIDâ€19 clinical sequelae of the pathophysiologic responses of hypercoagulability and thromboinflammation associated with acute infection. The acute lung injury that initially occurs in COVIDâ€19 results from vascular and endothelial damage from viral injury and pathophysiologic responses that produce the COVIDâ€19–associa
Document: Vascular endothelial injury is a hallmark of acute infection at both the microvascular and macrovascular levels. The hallmark of SARSâ€CoVâ€2 infection is the current COVIDâ€19 clinical sequelae of the pathophysiologic responses of hypercoagulability and thromboinflammation associated with acute infection. The acute lung injury that initially occurs in COVIDâ€19 results from vascular and endothelial damage from viral injury and pathophysiologic responses that produce the COVIDâ€19–associated coagulopathy. Clinicians should continue to focus on the vascular endothelial injury that occurs and evaluate potential therapeutic interventions that may benefit those with new infections during the current pandemic as they may also be of benefit for future pathogens that generate similar thromboinflammatory responses. The current Accelerating COVIDâ€19 Therapeutic Interventions and Vaccines (ACTIV) studies are important projects that will further define our management strategies. At the time of writing this report, two mRNA vaccines are now being distributed and will hopefully have a major impact on slowing the global spread and subsequent thromboinflammatory injury we see clinically in critically ill patients.
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