Selected article for: "influenza virus and vesicular stomatitis virus"

Author: Torres, Eva; Duque, María D.; López-Querol, Marta; Taylor, Martin C.; Naesens, Lieve; Ma, Chunlong; Pinto, Lawrence H.; Sureda, Francesc X.; Kelly, John M.; Vázquez, Santiago
Title: Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
  • Cord-id: 088gqxyz
  • Document date: 2012_1_1
  • ID: 088gqxyz
    Snippet: The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein.
    Document: The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein.

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