Author: Saitta, Laura; Molin, Alexandre; Villani, Flavio; Insorsi, Angelo; Roccatagliata, Luca; Inglese, Matilde; Bassetti, Matteo; Pelosi, Paolo; Castellan, Lucio; Gerevini, Simonetta; Robba, Chiara; Patroniti, Nicolò
Title: Brain microvascular occlusive disorder in COVID-19: a case report Cord-id: 2b0claqf Document date: 2020_10_9
ID: 2b0claqf
Snippet: We describe the case of a COVID-19 patient with severely impaired consciousness after sedation hold, showing magnetic resonance imaging (MRI) findings of (i) acute bilateral supratentorial ischemic lesions involving the fronto-parietal white matter and the corpus callosum and (ii) multiple diffuse susceptibility weighted imaging (SWI) hypointense foci, infra and supratentorial, predominantly bithalamic, suggestive of microhemorrhage or alternatively microthrombi. Severe acute respiratory syndrom
Document: We describe the case of a COVID-19 patient with severely impaired consciousness after sedation hold, showing magnetic resonance imaging (MRI) findings of (i) acute bilateral supratentorial ischemic lesions involving the fronto-parietal white matter and the corpus callosum and (ii) multiple diffuse susceptibility weighted imaging (SWI) hypointense foci, infra and supratentorial, predominantly bithalamic, suggestive of microhemorrhage or alternatively microthrombi. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA was detected in the cerebrospinal fluid. Our findings suggest the occurrence of vascular damage, predominantly involving microvessels. The underlying mechanisms, which include direct and indirect penetration of the virus to the central nervous system and systemic cardiorespiratory complications, are yet to be elucidated, and a direct correlation with SARS-CoV-2 infection remains uncertain.
Search related documents:
Co phrase search for related documents- acute ischemic lesion and magnetic resonance imaging: 1, 2
- acute phase and local systemic: 1, 2, 3, 4, 5
- acute phase and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute phase and macrophage activation syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute phase and magnetic resonance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute phase and magnetic resonance imaging: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- acute respiratory syndrome and local systemic: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and local thrombosis: 1, 2
- acute respiratory syndrome and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and macrophage activation syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and magnetic resonance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and magnetic resonance imaging: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- local systemic and macrophage activation: 1, 2
- local systemic and macrophage activation syndrome: 1
- local systemic and magnetic resonance: 1, 2, 3, 4, 5, 6
- local systemic and magnetic resonance imaging: 1, 2, 3, 4, 5
- macrophage activation and magnetic resonance: 1, 2
- macrophage activation and magnetic resonance imaging: 1
- macrophage activation syndrome and magnetic resonance imaging: 1
Co phrase search for related documents, hyperlinks ordered by date