Author: Williams, Spencer J.; Goddard-Borger, Ethan D.
Title: α-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19 Cord-id: 1nunkfln Document date: 2020_1_1
ID: 1nunkfln
Snippet: The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipitated social distancing measures that have crippled economic activities across the globe A return to normality is unlikely until effective therapeutics and a vaccine are available The immediacy of this problem suggests that drug strategies should focus on repurposing approved drugs or late-stage clinical candidates, as these have the shortest path to use in the clinic
Document: The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipitated social distancing measures that have crippled economic activities across the globe A return to normality is unlikely until effective therapeutics and a vaccine are available The immediacy of this problem suggests that drug strategies should focus on repurposing approved drugs or late-stage clinical candidates, as these have the shortest path to use in the clinic Here, we review and discuss the role of host cell N-glycosylation pathways to virus replication and the drugs available to disrupt these pathways In particular, we make a case for evaluation of the well-tolerated drugs miglitol, celgosivir and especially miglustat for the treatment of COVID-19
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