Decoupling the effects of nutrition, age and behavioral caste on honey bee physiology and immunity

Miguel Corona; Belen Branchiccela; Shayne Madella; Yanping Chen; Jay Evans

The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/667931 doi: bioRxiv preprint 389 significance of these correlations is considerably lower compared with the interactions among 390 DWV with vg and mrjp1. In contrast, the genes associated with foraging showed in general a 391 positive association with virus levels, with 33.33% of positive correlations and 0% of negative 392 correlations. In particular, ilp2 showed a higher percentage of positive correlations with virus 393 (42.66%), followed by ilp1 (33.33%) and mfe (25%). Virus-specific analyses reveal that both 394 DWV and BQCV exhibit 50% of positive correlations, while SBV does not show significant 395 interactions. The higher percentage of correlations between viruses and physiological genes 396 associated with foraging was observed in the interactions of ilp2 with DWV (75%) ( Table S3) . Table S3 ). This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.