Author: Andrade, Viviane M; Christensen-Quick, Aaron; Agnes, Joseph; Tur, Jared; Reed, Charles; Kalia, Richa; Marrero, Idania; Elwood, Dustin; Schultheis, Katherine; Purwar, Mansi; Reuschel, Emma; McMullan, Trevor; Pezzoli, Patrick; Kraynyak, Kim; Sylvester, Albert; Mammen, Mammen P; Tebas, Pablo; Joseph Kim, J; Weiner, David B; Smith, Trevor R F; Ramos, Stephanie J; Humeau, Laurent M; Boyer, Jean D; Broderick, Kate E
Title: INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants Cord-id: 0o1qog76 Document date: 2021_1_1
ID: 0o1qog76
Snippet: Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all
Document: Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.
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