Author: A. Sina Booeshaghi; Lior Pachter
Title: Decrease in ACE2 mRNA expression in aged mouse lung Document date: 2020_4_5
ID: 0pocrjvk_2
Snippet: To better assess the relationship between age and ACE2 expression, we examined single-cell RNA-seq data from eight 3-month old and seven 24-month old mouse lungs 6 in order to identify cell-type specific age-related differences, if any, in ACE2 mRNA expression. Single-cell RNA-seq can determine whether bulk shifts in gene expression are due to changes in cell-type abundances, or changes in gene expression within specific cell types 7 . We find th.....
Document: To better assess the relationship between age and ACE2 expression, we examined single-cell RNA-seq data from eight 3-month old and seven 24-month old mouse lungs 6 in order to identify cell-type specific age-related differences, if any, in ACE2 mRNA expression. Single-cell RNA-seq can determine whether bulk shifts in gene expression are due to changes in cell-type abundances, or changes in gene expression within specific cell types 7 . We find that both cell-type abundance shifts, as well as ACE2 mRNA changes in specific cell types, contribute to a decrease in ACE2 mRNA with age. We corroborate our findings with bulk RNA-seq analysis and ACE2 protein measurement in rat lungs 8 .
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