Author: Asif Shajahan; Nitin T. Supekar; Anne S. Gleinich; Parastoo Azadi
Title: Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2 Document date: 2020_4_3
ID: f0xsisdg_2
Snippet: The pathogenic SARS-CoV-2 enters human target cells via its viral transmembrane spike (S) glycoprotein. The spike protein is a trimeric class I fusion protein and consists of two subunits, namely S1 and S2. The S1 subunit facilitates the attachment of the virus, and subsequently the S2 subunit allows for the fusion of the viral and human cellular membranes (Hoffmann, M., Kleine-Weber, H., et al. 2020 , Walls, A.C., Park, Y.J., et al. 2020 , Zhou,.....
Document: The pathogenic SARS-CoV-2 enters human target cells via its viral transmembrane spike (S) glycoprotein. The spike protein is a trimeric class I fusion protein and consists of two subunits, namely S1 and S2. The S1 subunit facilitates the attachment of the virus, and subsequently the S2 subunit allows for the fusion of the viral and human cellular membranes (Hoffmann, M., Kleine-Weber, H., et al. 2020 , Walls, A.C., Park, Y.J., et al. 2020 , Zhou, P., Yang, X.L., et al. 2020 . The entry receptor for SARS-CoV-2 has been identified as the human angiotensin-converting enzyme 2 (hACE2), and recent studies determined a high binding affinity to hACE2 (Hoffmann, M., Kleine-Weber, H., et al. 2020 , Shang, J., Ye, G., et al. 2020 , Walls, A.C., Park, Y.J., et al. 2020 . Given its literal key role, the S protein is one of the major targets for the development of specific medical treatments or vaccines: neutralizing antibodies targeting the spike proteins of SARS-CoV-2 could prevent the virus from binding to the hACE2 entry receptor and therefore from entering the host cell (Shang, J., Ye, G., et al. 2020 ).
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