Selected article for: "RAS system and renin angiotensin"
Author: Namsolleck, Pawel; Recarti, Chiara; Foulquier, Sébastien; Steckelings, Ulrike Muscha; Unger, Thomas
Title: AT(2) Receptor and Tissue Injury: Therapeutic Implications
  • Cord-id: 0ycdbb9c
  • Document date: 2014_1_11
    • ID: 0ycdbb9c
    Snippet: The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT(1) receptor (AT(1)R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty years, protective actions of the RAS, not only in the cardiovascular, but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS inclu
    Document: The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT(1) receptor (AT(1)R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty years, protective actions of the RAS, not only in the cardiovascular, but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT(2)-receptors and Mas receptors (AT(2)R and MasR) and is characterized by effects different from and often opposing those of the AT(1)R. These include anti-inflammation, anti-fibrosis, anti-apoptosis and neuroregeneration that can counterbalance pathological processes and enable recovery from disease. The recent development of novel, small-molecule AT(2)R agonists offers a therapeutic potential in humans with a variety of clinical indications.

    Search related documents:
    Co phrase search for related documents
    • absence presence and activity expression: 1, 2, 3
    • absence presence and acute event: 1
    • absence presence and acute treatment: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • absence presence and adenine dinucleotide phosphate: 1
    • ace inhibitor and activity expression: 1, 2, 3, 4
    • ace inhibitor and activity increase expression: 1, 2
    • ace inhibitor and acute treatment: 1, 2, 3
    • ace inhibitor ramipril and activity expression: 1
    • ace inhibitor ramipril and activity increase expression: 1
    • activity expression and acute treatment: 1, 2, 3
    • activity expression and adenine dinucleotide phosphate: 1