Marburg Virus Disease: a Summary for Clinicians

Kortepeter, Mark G; Dierberg, Kerry; Shenoy, Erica S; Cieslak, Theodore J; Bhadelia, Nahid; Davey, Richard T; Evans, Jared D; Frank, Maria G; Grein, Jonathan; Kraft, Colleen S; Kratochvil, Chris J; Martins, Karen; McLellan, Susan; Measer, Greg; Mehta, Aneesh K; Raabe, Vanessa; Risi, George; Sauer, Lauren; Uyeki, Timothy

Abstract Objectives This article is a summary of countermeasures for Marburg virus disease focusing on pathogenesis, clinical features, and diagnostics, with an emphasis on therapies and vaccines that have demonstrated potential for use in an emergency situation, through their evaluation in nonhuman primates (NHPs) and/or in humans. Methods A standardized literature review was conducted on vaccines and treatments for each pathogen, with a focus on human and nonhuman primate data published in the last five years. More detail on the methods used are summarized in a companion methods paper. Results We identified six treatments and four vaccine platforms that have demonstrated potential benefit for treating or preventing infection in humans, through their efficacy in NHPs. Conclusion We provide succinct summaries of Marburg countermeasures to give the busy clinician a head start in reviewing the literature if faced with a patient with Marburg virus disease. We also provide links to other authoritative sources of information.