Author: Brosnahan, Shari B.; Jonkman, Annemijn H.; Kugler, Matthias C.; Munger, John S.; Kaufman, David A.
Title: COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions Cord-id: 0ddeuehn Document date: 2020_9_22
ID: 0ddeuehn
Snippet: The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndro
Document: The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions. GRAPHIC ABSTRACT: A graphic abstract is available for this article.
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