Author: Gupta, Satya P
Title: Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2. Cord-id: 0fte0ky1 Document date: 2020_9_22
ID: 0fte0ky1
Snippet: The article highlights an up-to-date progress in studies of structure and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, all CoVs including SARSCoV-2 are spherical positive single-stranded RNA viruses containing spike (S) protein, envelope (E) protein, nucleocapsid (N) protein, and membrane (M) protein, where S protein has a receptor-binding domain (RBD) that mediates the binding to host cell receptor, angioten
Document: The article highlights an up-to-date progress in studies of structure and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, all CoVs including SARSCoV-2 are spherical positive single-stranded RNA viruses containing spike (S) protein, envelope (E) protein, nucleocapsid (N) protein, and membrane (M) protein, where S protein has a receptor-binding domain (RBD) that mediates the binding to host cell receptor, angiotensin converting enzyme 2 (ACE2). The article details the repurposing of some drugs to be tried for COVID-19 and presents the status of vaccine development so far. Besides drugs and vaccines, the role of convalescent plasma (CP) therapy to treat COVID-19 is also discussed.
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