Pathology of the digestive tract and liver with COVID-19

Yakovenko, E. P.; Iakovenko, A. V.; Agafonova, N. A.; Ivanov, A. N.

The damage of gastrointestinal tract and liver is detected in more than half of patients with COVID-19. The disease can begin with gastroenterological manifestations, to which respiratory symptoms subsequently join. The presence of gastrointestinal and liver lesions in patients with COVID-19 worsens the disease prognosis and increases the risk of mortality. There are multiple mechanisms of digestive system damages: The direct cytolytic eff ect of the virus on the target cells with SARSCoV- 2 receptors on their surface, the action of components of systemic infl ammation, immunological and drug damages. The research of the use of rebamipide and ursodeoxycholic acid is a promising area in the treatment of COVID-19 patients with gastroenterological and liver lesions. © 2020 Global Media Tekhnologii.