Selected article for: "internal stability and siRNA internal stability"
Author: Asiedu Ebenezer
Title: Designing Effective small interfering RNA for Post-Transcriptional Silencing of Human GREM1: A Comprehensive Bioinformatics Approach
  • Document date: 2020_1_24
    • ID: j99qg2a0_24
    Snippet: Thermodynamics properties of duplex ends also define the silencing efficacy of siRNA in cells [30] . The internal stability of the high scoring siRNA candidates was evaluated with the Srna module available at Sfold and the results are shown in Figure 2 . Irrespective of how potential an siRNA is designed to be, gene silencing efficacy will be dependent on accessibility of the target site. As emphasized earlier, the stretch of nucleotides in the o.....
    Document: Thermodynamics properties of duplex ends also define the silencing efficacy of siRNA in cells [30] . The internal stability of the high scoring siRNA candidates was evaluated with the Srna module available at Sfold and the results are shown in Figure 2 . Irrespective of how potential an siRNA is designed to be, gene silencing efficacy will be dependent on accessibility of the target site. As emphasized earlier, the stretch of nucleotides in the open reading frame for human gremlin-1 was used as the target for the siRNA design.

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