Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases

Quispe, Cristina; Cruz-Martins, Natália; Manca, Maria Letizia; Manconi, Maria; Sytar, Oksana; Hudz, Nataliia; Shanaida, Mariia; Kumar, Manoj; Taheri, Yasaman; Martorell, Miquel; Sharifi-Rad, Javad; Pintus, Gianfranco; Cho, William C.

Due to its vast therapeutic potential, the plant-derived polyphenol curcumin is utilized in an ever-growing number of health-related applications. Here, we report the extraction methodologies, therapeutic properties, advantages and disadvantages linked to curcumin employment, and the new strategies addressed to improve its effectiveness by employing advanced nanocarriers. The emerging nanotechnology applications used to enhance CUR bioavailability and its targeted delivery in specific pathological conditions are collected and discussed. In particular, new aspects concerning the main strategic nanocarriers employed for treating inflammation and oxidative stress-related diseases are reported and discussed, with specific emphasis on those topically employed in conditions such as wounds, arthritis, or psoriasis and others used in pathologies such as bowel (colitis), neurodegenerative (Alzheimer's or dementia), cardiovascular (atherosclerosis), and lung (asthma and chronic obstructive pulmonary disease) diseases. A brief overview of the relevant clinical trials is also included. We believe the review can provide the readers with an overview of the nanostrategies currently employed to improve CUR therapeutic applications in the highlighted pathological conditions.