Prevention of COVID-19 in pregnant women, eventual use of new vaccines

Cuadra-Sánchez, C.; Rivero, A.; Cabrera, C.; Faneite, P.; de Gracia, P. V.

Pregnant women who have COVID-19 have an increased risk of hospitalization and death;however, there are many restrictions for the application of COVID-19 vaccines on pregnant patients, mainly because there is no confirmation of the safety of their use during pregnancy. None of the vaccines approved to date are based on live attenuated SARS-CoV-2, so the possibility of generating an infection in the fetus is nonexistent. Likewise, current evidence does not suggest that COVID-19 vaccines can induce a complication or adverse pregnancy outcome and due to the emergence of new waves of COVID-19, the potential protective benefits of these vaccines far outweigh the possible risks in most patients. A review of the evidence of the safety of COVID-19 vaccines, recommendations, and restrictions for the use of COVID-19 vaccines in pregnant women made by international health organisms and professional associations, as well as prospects and information on clinical trials of these vaccines in pregnant women are presented. © 2021 Academia Nacional de Medicina. All rights reserved.