Author: Tsuneki-Tokunaga, Akeno; Kanai, Kyosuke; Itagaki, Asao; Tsuchie, Hideaki; Okada, Takayoshi; Kasagi, Masaaki; Tanaka, Kiyoshi; Aoki, Miho; Hinay, Alfredo Jr. A.; Kageyama, Seiji
Title: Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic Cord-id: 0hp48xjg Document date: 2021_2_12
ID: 0hp48xjg
Snippet: The correlation of viral growth capability (n = 156) with the viral load in nasopharyngeal swabs (n = 76) was assessed. Epidemic influenza A/H1N1, A/H3N2, and B viruses showed a wide range of growth capability (10(4)–10(11) copies/mL) in Madin-Darby canine kidney cells. The growth was correlated with the nasopharyngeal viral load (r = 0.53). Six selected strains showed growth-dependent cell death (r = 0.96) in a growth kinetics assay. Epidemic influenza viruses exhibit a wide range of growth c
Document: The correlation of viral growth capability (n = 156) with the viral load in nasopharyngeal swabs (n = 76) was assessed. Epidemic influenza A/H1N1, A/H3N2, and B viruses showed a wide range of growth capability (10(4)–10(11) copies/mL) in Madin-Darby canine kidney cells. The growth was correlated with the nasopharyngeal viral load (r = 0.53). Six selected strains showed growth-dependent cell death (r = 0.96) in a growth kinetics assay. Epidemic influenza viruses exhibit a wide range of growth capability. Growth capability should be considered one of the key factors in disease prognosis.
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