The d614g mutation in severe acute respiratory syndrome coronavirus 2 (Sars-cov-2) spike glycoprotein: A mini-report

Ansori, A. N. M.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a quickly spreading virus that poses a major burden on global human health. Thus, it is essential to develop COVID-19 vaccines. Vaccine development might not be easy, as a consequence of mutations. This study aimed to demonstrate the D614G mutation in SARS-CoV-2 spike glycoprotein from Indonesia. 102 isolates from the GISAID EpiCoV database and the Wuhan-Hu-1 isolate (reference sequence) from GenBank, NCBI were used in this study. BioEdit employed to examine the D614G mutation in the spike glycoprotein of SARS-CoV-2. In this report, there are 56 D614G mutations among 102 SARS-CoV-2 isolates. In summary, this report might suggest that the D614G mutation implicates the COVID-19 pandemic in Indonesia. Nevertheless, this report was a preliminary study and this study recommends expanding molecular epidemiology and surveillance programs to monitor COVID-19.