Author: Matthew Levin; Martin D Chen; Anjan Shah; Ronak Shah; George Zhou; Erica Kane; Garrett Burnett; Shams Ranginwala; Jonathan Madek; Christopher Gidiscin; Chang Park; Daniel Katz; Benjamin Salter; Roopa Kohli-Seth; James B Eisenkraft; Suzan Uysal; Michael McCarry; Andrew B Leibowitz; David L Reich
Title: Differential ventilation using flow control valves as a potential bridge to full ventilatory support during the COVID-19 crisis Document date: 2020_4_21
ID: djul495n_44
Snippet: We have successfully demonstrated that patients of differing size and lung compliance can be independently ventilated with different tidal volumes and pressures using a single ventilator and a split circuit system with flow control valves. The clinical performance of this novel circuit was predicted using high fidelity simulation. We were able to compensate for respiratory acidosis in one patient without affecting the other. All patients remained.....
Document: We have successfully demonstrated that patients of differing size and lung compliance can be independently ventilated with different tidal volumes and pressures using a single ventilator and a split circuit system with flow control valves. The clinical performance of this novel circuit was predicted using high fidelity simulation. We were able to compensate for respiratory acidosis in one patient without affecting the other. All patients remained hemodynamically stable without any negative effect on oxygenation. This approach may be used as a bridge to a next level of therapy, providing acute mechanical ventilation for a short period of time while the next best course of action is determined. Further evaluation is needed to confirm that this system may also be used for longer periods of time. A rapid innovation will be addition of purpose-designed calibrated PEEP valves in the expiratory limbs. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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