Author: Xiaohua Chen; Binghong Zhao; Yueming Qu; Yurou Chen; Jie Xiong; Yong Feng; Dong Men; Qianchuan Huang; Ying Liu; Bo Yang; Jinya Ding; Feng Li
Title: Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients Document date: 2020_3_3
ID: g41pd9uz_31
Snippet: Although recent studies have shown that IL-6 level increased in severe patients 14 , its level in COVID-19 critically ill patients is still unknown. IL-6 is one of the major pro-inflammatory factors that contribute to the formation of cytokine storm, which largely enhance the vascular permeability and impair the organs function. This observation might help to explain that why serum SARS-CoV-2 viral RNA was only able to be detected in patients wit.....
Document: Although recent studies have shown that IL-6 level increased in severe patients 14 , its level in COVID-19 critically ill patients is still unknown. IL-6 is one of the major pro-inflammatory factors that contribute to the formation of cytokine storm, which largely enhance the vascular permeability and impair the organs function. This observation might help to explain that why serum SARS-CoV-2 viral RNA was only able to be detected in patients with extremely high level of IL-6. We still could not rule out the possibility that SARS-CoV-2 virus amount grow explosively in a short period, which in turn induced the massive cytokine storm that characterized by elevated level of cytokines such as IL-6. We have to point out that due to the shortage of detection kit, the results of other cytokines could not be obtained and those investigations should be warranted in future study.
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