Author: Armin Ensser; Klaus Ueberla
Title: Determination of daily reproduction numbers of SARS-CoV2 based on death cases suggests more rapid initial spread in Italy and the United States Document date: 2020_3_31
ID: 4izymiy4_23
Snippet: The assay is specific for integration. When CEM-SS-R5 cells are acutely infected in the presence of the diketo acid integrase inhibitor L-731,988 (Merck) (21) , no integration is detectable (Fig. 5C ). That is, only a fivefold bidirectional Alu-gag amplification was seen with L-731,988 inhibition, a signal similar to that of a gag-only preamplification. The signals obtained from infections performed using the HIV-1 YU2 -derived integrase mutant D.....
Document: The assay is specific for integration. When CEM-SS-R5 cells are acutely infected in the presence of the diketo acid integrase inhibitor L-731,988 (Merck) (21) , no integration is detectable (Fig. 5C ). That is, only a fivefold bidirectional Alu-gag amplification was seen with L-731,988 inhibition, a signal similar to that of a gag-only preamplification. The signals obtained from infections performed using the HIV-1 YU2 -derived integrase mutant D64A were also dramatically reduced, again to a level similar to that of a gag-only preamplification (Fig. 5D ).
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