Selected article for: "analysis tool and enrichment analysis tool"
Author: Laura Riva; Shuofeng Yuan; Xin Yin; Laura Martin-Sancho; Naoko Matsunaga; Sebastian Burgstaller-Muehlbacher; Lars Pache; Paul P. De Jesus; Mitchell V. Hull; Max Chang; Jasper Fuk-Woo Chan; Jianli Cao; Vincent Kwok-Man Poon; Kristina Herbert; Tu-Trinh Nguyen; Yuan Pu; Courtney Nguyen; Andrey Rubanov; Luis Martinez-Sobrido; Wen-Chun Liu; Lisa Miorin; Kris M. White; Jeffrey R. Johnson; Christopher Benner; Ren Sun; Peter G. Schultz; Andrew Su; Adolfo Garcia-Sastre; Arnab K. Chatterjee; Kwok-Yung Yuen; Sumit K. Chanda
Title: A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals
  • Document date: 2020_4_17
    • ID: 1fgnfh62_22
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.044016 doi: bioRxiv preprint to a variety of properties, including targets, pathways, indications, and mechanisms of actions (MOA). Each annotation property was tested for enrichment among the screening hits using the GSEA software 38, 39 . The compounds annotated for each property were treated as a "gene set". For each set of vendor a.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.044016 doi: bioRxiv preprint to a variety of properties, including targets, pathways, indications, and mechanisms of actions (MOA). Each annotation property was tested for enrichment among the screening hits using the GSEA software 38, 39 . The compounds annotated for each property were treated as a "gene set". For each set of vendor annotations, the background compound set was defined as the set of compounds annotated for any property by that vendor. Enrichment results at p < 0.05 and FDR q-value < 0.25 were defined as significant. Additional enrichment analyses were performed using the free online meta-analysis tool Metascape 40 .

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