Discovery of pharmaceutically-targetable pathways and prediction of survivorship for pneumonia and sepsis patients from the view point of ensemble gene noise

Tristan de Jong; Victor Guryev; Yury M. Moshkin

We also identified 5 gene ensembles for which ensemble gene noise was positively and significantly correlated with the disease state in H1N1 and CAP patients ( Figure 2A , Table S1B ). However, ensemble gene noise for these pathways was also significantly increased in sepsis patients (t-test, Bonferroni adjusted p < 0.01) despite insignificant rank correlation. To that, some of these pathways can be implicated in the pathology of sepsis ( Table 1) . Two of these ensembles were represented by genes encoding mitochondrial respiratory chain complex I (Complex I) ( Figure 2C ). From the point of view of ensemble gene noise this suggests an altered stoichiometry and gene noise in the expression of the subunits of the Complex I which, as a result, might lead to its improper assembly and function in H1N1, CAP and sepsis patients.