Author: Tristan de Jong; Victor Guryev; Yury M. Moshkin
Title: Discovery of pharmaceutically-targetable pathways and prediction of survivorship for pneumonia and sepsis patients from the view point of ensemble gene noise Document date: 2020_4_11
ID: f5w05rc2_7
Snippet: Because of the fluctuation-response relationship [18] , absolute changes in the mean log gene expressions (|ï„ï|) in response to infection (CAP, H1N1) and sepsis correlated significantly with the variances of the log gene expressions ( Figure 1B) . Interestingly, we also noted significant correlations between the absolute changes in inter-individual gene expression variabilities (|ï„ï³ 2 |) and the variances of log genes expressions ( Figure.....
Document: Because of the fluctuation-response relationship [18] , absolute changes in the mean log gene expressions (|ï„ï|) in response to infection (CAP, H1N1) and sepsis correlated significantly with the variances of the log gene expressions ( Figure 1B) . Interestingly, we also noted significant correlations between the absolute changes in inter-individual gene expression variabilities (|ï„ï³ 2 |) and the variances of log genes expressions ( Figure 1C ). Consequently, |ï„ï| and |ï„ï³ 2 | were also correlated ( Figure 1D ). Thus, we conclude that H1N1, CAP and sepsis result in coordinated changes in both the mean and heterogeneity of the expression of genes and that magnitudes of these changes depend on genes' biological coefficients of variation.
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